Cell Biology
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IL-7 is a hematopoietic growth factor with a key impact on early B and T cells. It originates from thymic stromal cells, spleen cells, and keratinocytes. In addition to its primary effects, IL-7 can collaborate with other factors like ConA and IL-2 to stimulate the proliferation of mature T cells. I..
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M-CSF, a potent hematopoietic factor, is generated by a variety of cells such as lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It serves as a crucial regulator of cellular proliferation, differentiation, and survival for blood monocytes, t..
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PDGFs are dimers linked by disulfide bonds, composed of two 12.0-13.5 kDa polypeptide chains known as PDGF-A and PDGF-B. Among the three naturally occurring PDGFs (PDGF-AA, PDGF-BB, and PDGF-AB), they act as potent mitogens for various cell types such as smooth muscle cells, c..
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The three mammalian isoforms of TGF-β, namely TGF-β1, β2, and β3, activate the same receptor and provoke similar biological responses. These versatile cytokines oversee cell proliferation, growth, differentiation, and motility, along with orchestrating the ..
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TNF-α, a versatile pro-inflammatory cytokine, is produced by various cell types such as adipocytes, activated monocytes, macrophages, B cells, T cells, and fibroblasts. It belongs to the TNF ligand family and interacts with two receptors, TNFR1 and TNFR2. Its functions i..
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TPO, a growth factor specific to certain lineages, emerges from the liver, kidney, and skeletal muscle. Its primary function involves stimulating the proliferation and maturation of megakaryocytes while fostering an increase in circulating platelet levels in vivo. TPO transmit..
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VEGF stands out as a potent cytokine, driving growth and angiogenesis. It fosters endothelial cell proliferation and survival, contributing significantly to angiogenesis and vascular permeability. Its expression in vascularized tissues plays a crucial role in both normal and a..
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LB broth (Lennox formulation) is a ready-to-use liquid growth medium used for bacterial culture. Gibco LB Broth is filter-sterilized and can be used for nearly all applications that require a liquid bacteria culturing step, such as protein expression, cloning, and expansion.LB broth is one of the mo..
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Leibovitz's L-15 Medium supports the growth of HEP-2 monkey kidney cells and primary explants of embryonic and adult human tissue. L-15 is buffered by phosphates and free base amino acids instead of sodium bicarbonate. This medium is designed for supporting cell growth in environments without CO2 eq..
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